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. 2018 Nov 29;12:290. doi: 10.3389/fnbeh.2018.00290

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Copyright © 2018 Wang, Cai and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metformin treatment did not alter exploratory locomotion in the open field in B6 or BTBR mice. (A) The representative traces of different group mice in open field test show a 30-min assay of distance moved and time in center were computationally split into six segments with 5 min per segment. Compared with vehicle treated group, early metformin treatment did not have effects on distance traveled (B) and time spend in center (C) in each segment. Across the 30-min test, total distance traveled (D) and time in center (E) was not affected by early metformin treatment in B6 and BTBR mice. Data are presented as the means ± SEM. n = 10. *p < 0.05, **p < 0.01.