Table 1.
Current malaria vaccines in clinical trials.
| Vaccine candidate | Clinical trial registration number | Clinical trial stage |
|---|---|---|
| PRE-ERYTHROCYTIC | ||
| RTS,S/AS01 | NCT01345240 | Phase 3 |
| R21/AS01B | NCT02600975 | Phase 1 |
| R21/ME-TRAP | NCT02905019 (53) | Phase 2 |
| ChAd63/MVA ME-TRAP | NCT01635647 (54–56) | Phase 2 |
| R21/Matrix-M1 | NCT02572388/NCT02925403 | Phase 1/2 |
| PfSPZ Vaccine | NCT03510481 | Phase 1 |
| PfSPZ-CVac (PfSPZ Challenge + chloroquine or + chloroquine/pyrimethamine | NCT03083847 | Phase 1 |
| GAP 3KO (52-/36-/sap1-) | NCT02313376 | Phase 1 |
| BLOOD-STAGE | ||
| pfAMA1-DiCo | NCT02014727 (57) | Phase 1 |
| P27A | NCT01949909 | Phase 2 |
| PAMVAC | NCT02647489 | Phase 1 |
| PRIMVAC | NCT02658253 | Phase 1 |
| SEXUAL-STAGE | ||
| ChAd63 Pfs25-IMX313/MVA Pfs25-IMX313 | NCT02532049 | Phase 1 |
| Pfs25-EPA/Alhydrogel | NCT01867463, 51 | Phase 1 |
| Pfs230D1M-EPA/Alhydrogel and/or Pfs25-EPA/Alhydrogel | NCT02334462 | Phase 1 |
| Pfs25M-EPA/AS01 and/or Pfs230D1M-EPA/ASOI | NCT02942277 | Phase 1 |
| Pfs25 VLP-FhCMB | NCT02013687 | Phase 1 |
| Pfs25-Pfs25 | NCT00977899 | Phase 1 |
| Pfs25 & Pvs/Monatide ISA 51 | NCT00295581 | Phase 1 |
Adapted from WHO. 9/28/2018. Malaria Vaccine Rainbow Tables. http://www.who.int/vaccine_research/links/Rainbow/en/index.html.