Table 3.

Five examples where modulating the same pathway yields different outcomes. This table shows the 5 day survival using a CLP model of sepsis. The treatment targeted the same molecule or pathway, but the outcomes were different. This table highlights how a standardized sepsis model may be used to define the role of a potential mediator in the pathogenesis of sepsis. Currently an investigator may selectively cite the literature which supports her/his position to further investigate the molecule of choice.

Molecule or pathway	Better		Worse or no change
	Control	Treated	Control	Treated
Cannabinoid 2 receptor	20%	60% (34)	60%	20% (35)
Leukotriene synthesis inhibitor (MK886)	23%	100% (68)	90%	43% (69)
Anti-IL-6	60%	100% (70)	78%	80% (71)
Cyclooxygenase 2	0%	45% (72)	65%	20% (73)
Adenosine 2B receptor	40%	80% (74)	95%	50% (75)