Table 4.

Examples of the technical elements that could be standardized in the CLP sepsis model. CLP would be one of the models where standardization could be achieved, but would not be the only standardized sepsis model.

Surgical considerations Peritoneal cavity closure method Skin closure method Analgesia Need for second surgery to remove necrotic cecum Size of needle used for puncture Mortality % mortality # of days to follow for mortality Perioperative care Antibiotics yes or no Duration and type of antibiotics Fluid resuscitation including route Anesthesia for surgery Humane endpoints for euthanasia Location of venous sampling Post-op warming and delivery of oxygen Timing of therapeutic interventions