Table 2:

Mean differences in CV markers by BMI and WHr overweight status groups compared to the lean group by multivariate analysis

	CV Marker
	LVMI	Triglyceride (mg/dL)†	HDL-C (mg/dL)	NonHDL-C (mg/dL)	FGF23 (RU/mL)†	SBP z-score	DBP z-score	Glucose (mg/dL)
Lean [REFERENCE] Mean(95%CI)	27.4 (25.5-29.3)	94.5 (85.5-104.6)	57.9 (55.0-60.7)	120.7 (113.8-127.7)	128.8 (114.1-145.5)	0.08 (−0.10-0.25)	0.32 (0.17-0.47)	89.1 (87.1- 91.0)
WHr Overweight Mean difference vs. reference	+2.74* p=0.004	+17.1%* p=0.001	−3.71* p=0.004	+6.04* p=0.043	−6.4% p=0.266	+0.08 p=0.301	−0.0003 p=0.996	+1.2% p=0.339
BMI Overweight Mean difference vs. reference	+2.10 p=0.192	+4.0% p=0.620	−0.42 p=0.841	+6.33 p=0.192	−8.3% p=0.322	+0.01 p=0.961	−0.05 p=0.624	+1.3% p=0.526
Both WHr&BMI Mean difference vs. reference	+4.51* p<0.001	+43.6%* p<0.001	−6.48* p<0.001	+15.40* p<0.001	−4.7% p=0.314	+0.34* p<0.001	+0.03 p=0.649	+3.0%* p=0.003

^*Difference in the CV parameter between the overweight group and the lean (reference) group is significant (p<0.05), adjusted for age centered at 10, eGFR centered at 50, glomerular diagnosis, black race, pubertal status and male gender

^†Differences in log transformed variables are presented as % change from reference group