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. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2018 Jun 6;353:23–30. doi: 10.1016/j.taap.2018.06.003

Fig. 7. Constitutively high levels of p62 and Nrf2 in cadmium-transformed BEAS-2BR cells and p62 positively regulated Nrf2, which had a positive feedback relationship with p62.

Fig. 7

(A) Constitutively high levels of p62 and Nrf2 in cadmium-transformed cells. Whole cell lysates from cadmium-transformed cells (CdT) and their passage-matched untransformed cells (BEAS-2BR) were isolated. Protein levels of p62 and Nrf2 were analyzed using immunoblotting. (B) p62 positively regulates Nrf2, which has a positive feedback relationship with p62 in cadmium-transformed cells. These cells with or without knockdown of p62 or Nrf2 were cultures in 100 mm dishes. Whole cell lysates were isolated. Protein levels of p62 and Nrf2 were analyzed using immunoblotting.