Table 2.

Genomic studies of gonococcus

Location	Year	n	Resistant isolates without known mechanisms	Reference	Accession
United States	2009–2010	236	-	Grad et al. 201450	PRJEB2999
Canada	1982–2008	25	-	Vidovic et al. 2014159	-
Canada	1989–2013	169	27 CRO-RS without mosaic penA	Demczuk et al. 2015160	PRJNA266539
Global	1982–2013	61	1 CFX-RS 1 AZI-RS 1 TET-R	Ezewudo et al. 201521	SRA099559
England	2014–2015	15	-	Chisholm et al. 201678	-
France	2010–2014	4	1 AZI-RS	de Curraize et al. 2016161	PRJEB13093
Canada	1989–2014	236	-	Demczuk et al. 2016162	SRP065041
UK	2004–2015	1842	-	De Silva et al. 201624	PRJNA315363
UK	1995–2000	237	-	Didelot et al. 2016107	PRJEB2124
United States	2000–2013	1102	106 AZI-RS 5 CIP-R	Grad et al. 201622	PRJEB7904
Global		289	-	Harrison et al. 201637	Previously published
Europe	2009–2014	75	-	Jacobsson et al. 201679	PRJNA322768
Global		14	-	Unemo et al. 2016139	PRJEB14020
UK	2014–2015	100	-	Peters et al. 2017111	Previously published
US, Brazil		804 + 118	-	Vidyaprakash et al. 2017163	Previously published
Ireland	2008–2014	14	-	Mac Aogáin et al. 2017164	PRJNA275092
New Zealand	2014–2015	398	2 CIP-R 6 Spec-RS 1 CFX-RS	Lee et al. 201723	PRJNA394216
US (Hawaii)	2011–2016	61	-	Papp et al. 201790	-
Australia	2005–2014	94		Kwong et al. 2017165	PRJEB17738
Brazil	2006–2015	116	3 PEN-R	Costa-Lourenço et al. 2018166	-
Australia	2012–2014	94	-	Buckley et al. 2018112	PRJNA392203
UK	2014–2017	180	-	Fifer et al. 2018167	PRJEB23008
Australia	2011–2013	59	-	Al Suwayyid et al. 2018168	-
Kenya	2010–2015	103	-	Cehovin et al. 2018169	PRJEB10104
Japan, Australia	2015, 2017	4	-	Lahra et al. 2018170	PRJNA416507

Studies were included when > 1 isolate was sequenced. -R = resistant, -RS = reduced susceptibility.