Table 1.
Age, BMI and pulmonary function testing presented as mean with standard deviation. CALIPER data presented as median with interquartile range. Two-tailed T tests and Wilcoxon Rank Sum tests were used to determine significance. Severity scores compared by chi square.
| Cases (n = 77) | Controls (n = 19) | P | |
|---|---|---|---|
|
| |||
| Age | 62.2 (± 13.4) | 45.2 (± 15.1) | 0.0001 |
|
| |||
| BMI (kg/m2) | 28.7 (± 5.9) | 25.7 (± 3.7) | 0.008 |
|
| |||
| Gender | 0.39 | ||
| M | 34 (44%) | 9 (47%) | |
| F | 43 (56%) | 10 (53%) | |
|
| |||
| FEV1 % predicted | 73.9% (± 19.0) | 102.5% (± 8.7) | <0.0001 |
|
| |||
| FVC % predicted | 72.1% (± 17.9) | 102.4% (± 9.6) | <0.0001 |
|
| |||
| FEV1/FVC | 85.2 (± 11.4) | 80.5 (± 4.9) | 0.008 |
|
| |||
| CALIPER | |||
| Normal | 51.9% (39.3 – 63.2) | 93.5% (84.5 – 98.3) | <0.0001 |
| Ground glass | 34.5% (20.9 – 50.7) | 0% (0 – 0) | <0.0001 |
| Reticular | 8.2% (3.0 – 13.6) | 0% (0 – 0) | <0.0001 |
| Honeycomb | 0% (0 – 0.2) | 0% (0 – 0) | 0.001 |
| ILA | 45.1% (35.3 – 60.6) | 0% (0 – 0) | <0.0001 |
|
| |||
| Radiologic severity score | |||
| 0 | 0 (0%) | 16 (84.2%) | <0.0001 |
| 1 | 19 (26.8%) | 3 (15.8%) | |
| 2 | 35 (49.3%) | 0 | |
| 3 | 17 (23.9%) | 0 | |
|
| |||
| Clinical severity score | |||
| 0 | 4 (5.2%) | 19 (100%) | <0.0001 |
| 1 | 15 (19.5%) | 0 | |
| 2 | 39 (50.7%) | 0 | |
| 3 | 19 (24.7%) | 0 | |