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. 2018 Nov 29;9:2771. doi: 10.3389/fimmu.2018.02771

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Copyright © 2018 Arleevskaya, Albina, Larionova, Gabdoulkhakova, Lemerle and Renaudineau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Study cohort. (A) The 20-year longitudinal Tatarstan women cohort is subdivided in three groups: women with newly diagnosed rheumatoid arthritis (< 1 year from diagnosis, new RA), unaffected first degree relatives (FDR), and healthy controls that are age matched with FDR. Among FDR, a subgroup has developed RA during its follow-up and was referred as FDR-RA in contrast to non-RA FDR who have not developed RA. (B) Follow-up of the 26 FDR having developed RA and for each individual available data are indicated according to the year of diagnosis (time = 0). n, number.