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. 2018 Nov 29;9:2771. doi: 10.3389/fimmu.2018.02771

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Copyright © 2018 Arleevskaya, Albina, Larionova, Gabdoulkhakova, Lemerle and Renaudineau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Infection prevalence, incidence and duration are increased in the FDR-RA subgroup at baseline. (A,B): total (A) and individual (B) infection prevalence in the previous year in controls, non-RA FDR, FDR-RA and new RA. (C,D): total (C) and individual (D) infection incidence (number of event/year). (E,F): total (E) and individual (F) infection duration (day/event/year). new RA, newly diagnosed RA patients; FDR, first degree relatives; FDR-RA, FDR individuals having developed RA; FDR, individuals not having developed RA; URI, upper respiratory infections; HSV, herpes simplex virus infection. Hatched squares mean that no data were available. Statistics are indicated when p < 0.05 and for individual infections the p-values were corrected using the Benjamini–Hochberg method (58 tests).