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. 2018 Nov 29;9:2819. doi: 10.3389/fimmu.2018.02819

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Copyright © 2018 Mähler, Balogh, Csizmadia, Klug, Kleinewietfeld, Steiniger, Šušnjar, Müller, Boschmann and Paul.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequency of IL-17A and TNFα producing T cells. Frequencies of (A) total IL-17A⁺, (B) IL-17A⁺ TNFα⁻, (C) IL-17A⁺ TNFα⁺, and (D) TNFα⁺ CD4⁺ cells in MS patients after 4 weeks of normoxic (NO, n = 16, black circles) and hypoxic (HO, n = 14, gray circles) treadmill training. Three samples not analyzed due to quality issues. Comparison of training effects (ΔV2-V1, right column). P-values before vs. after training by Student's paired t-test or Wilcoxon signed rank test. P-values NO vs. HO by Mann-Whitney U test or Student's t-test.