Table 4.

Univariate and multivariate Cox regression analysis of the correlation between the 4-gene signature and clinical features in GSE49710.

	Univariate analysis			Multivariate analysis
Variables	P-value	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI
4-gene signature	<0.0001	1.095	1.079–1.112	<0.0001	1.958	1.530–2.507
Age group	<0.0001	7.634	4.678–12.458	0.098	1.716	0.904–3.256
MYCN amplified	<0.0001	6.001	4.048–8.896	0.166	1.386	0.874–2.198
High risk	<0.0001	16.643	9.274–29.868	0.323	1.666	0.606–4.583
INSS stage	<0.0001	3.123	2.300–4.241	0.023	1.563	1.063–2.297

Overall survival. Bold values emphasize p < 0.05.