TABLE 4.
Category | Isolate PCR | Direct swab PCR | WGS |
---|---|---|---|
All meningococci | Any sample in which the porA and/or ctrA gene(s) was detected | Any sample in which the porA and/or ctrA gene(s) and/or the group B capsule gene was detected | Any sample in which the porA and/or ctrA sequences were predicted to encode full-length gene product |
Grouped meningococci | Any sample in which the porA and/or ctrA gene(s) and the relevant group capsule gene were detected | Performed only for NmB | Any sample in which the porA and/or ctrA sequences and all the required genes for synthesis and transport of the relevant capsule group were predicted to encode full-length gene products |
Nongroupable meningococci | Any sample in which the porA and/or ctrA gene(s) was detected but no capsule gene was detected | Not applicable | Any sample in which the porA and ctrA sequences were predicted to encode full-length gene product and lacking any of the required genes for synthesis and transport of the relevant capsule group OR any sample in which the ctrA sequence is incomplete |
Non-NmB meningococci | Not applicable | Any sample in which the porA and/or ctrA gene(s) was detected but the group B capsule gene was not detected | Not applicable |
Group B meningococci | See “Grouped meningococci” above | Any sample in which the group B capsule gene was detected | See “Grouped meningococci” above |
Abbreviations: NmB, Neisseria meningitidis serogroup B; WGS, whole-genome sequencing.