FIGURE 7.

Effect of PTS in an in vivo anti-tumor xenograft model. The nude mice were subcutaneously injected with PC-3 cells (10⁷ cell/mouse). The tumors were measured every day. When the tumors reached to a volume of 100 mm³, the mice were divided into two groups and intraperitoneal PTS injection was initiated. (A) The length (l) and width (w) of the tumor were measured, and tumor volume was calculated as lw²/2. (B) The body weight was also measured. The protocols of the in vivo study were approved by the Animal Care and Use Committee at National Taiwan University. All animal procedures and protocols were approved by AAALAC-accredited facility. (C) The p-Akt expression of randomly selected six tumors in both control and PTS groups has been detected. Data are expressed as mean ± SD.