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. 2018 Nov 28;12:448. doi: 10.3389/fncel.2018.00448

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Copyright © 2018 Weise, Villarreal, Heidrich, Dehghanian, Schachtrup, Nestel, Schwarz, Thedieck and Vogel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MFGE8-positive astrocytes partially originate from FOXG1-cre expressing progenitors. (A) Lineage tracing of FOXG1-expressing cells with a YFP reporter mouse line demonstrates that MFGE8 astrocytes can derive from FOXG1-expressing and other progenitors in (A) cerebral cortex (CTX) and hippocampus (HIP) and in (B) the caudate putamen (cPA). Magnifications show single MFGE8- and YFP-positive (MFGE8+/YFP+) cells in (a”) cerebral cortex, (a”’) hippocampus and (b”,b”’) caudate putamen. MFGE8+/YFP-negative cells are illustrated in (a’) the cerebral cortex and in (b’) the caudate putamen. Scale bar: 10 μm, n = 3. (C) Overview images of representative rostral and caudal forebrain section after immunofluorescence for MFGE8 and GFP show the region analyzed in (A,B) as indicated.