TABLE VI. Parasitaemia (%) of Plasmodium berghei and its reduction in mice treated with Chloroquine (CQ) at sub-curative doses, alone or combined with Accuvit® .
| Drugs | Dose (mg/kg) | % Reduction of parasitaemia (mean parasitaemia ± SD)* | Survival (average ± SD) | ||
| 5th | 7th | 9th | |||
| Non-treated mice | 0 | 0.8 ± 0.8 | 14.8 ± 6.0 | 11.8 ± 3.0 | 19 ± 3 |
| Accuvit® | 25 | 78 (0.2 ± 0.04) | 44 (8.3 ± 2.1) | 20 (9.5 ± 2.4) | 21 ± 4 |
| 50 | 77 (0.2 ± 0.2) | 60 (5.9 ± 5.3) | 26 (8.8 ± 2.2) | 22 ± 5 | |
| Chloroquine | 1.25 | 93 (0.1 ± 0.03) | 49 (7.6 ± 3.3) | 56 (5.1 ± 0.1) | 19 ± 4 |
| 2.5 | 95 (0.01 ± 0.1) | 79 (3.1 ± 5.3) | 29 (8.4 ± 4.5) | 20 ± 9 | |
| 5 | 94 (0.0 ± 0.1) | 69 (4.7 ± 4.0) | 57 (5.1 ± 3.1) | 24 ± 4 | |
| CQ + Accuvit® | 1.25 : 25 | 89 (0.1 ± 0.01) | 36 (9.5 ± 0.8) | 20 (9.4 ± 3.5) | 18 ± 5 |
| 2.5 : 25 | 82 (0.1 ± 0.2) | 64 (5.3 ± 6.5) | 49 (6.0 ± 1.9) | 22 ± 6 | |
| 5 : 25 | 90 (0.1 ± 0.1) | 56 (6.6 ± 2.5) | 27 (8.6 ± 4.4) | 19 ± 4 | |
| CQ + Accuvit® | 1.25 : 50 | 53 (0.4 ± 0.3) | 9 (13.4 ± 6.0) | 0 (11.9 ± 4.5) | 27 ± 3 |
| 2.5 : 50 | 67 (0.3 ± 0.1) | 60 (5.9 ± 1.2) | 33 (8.0 ± 4.6) | 24 ± 5 | |
| 5 : 50 | 100 (0.0 ± 0.0) | 80 (3.0 ± 4.2) | 31 (8.2 ± 2.0) | 24 ± 6 | |
*: reduction of parasitaemia in relation to untreated controls; when < 30% = inactive, 30-40% = partially active and > 40% = active.