Table 2.
Methodological quality of randomized clinical trials included in the meta-analysis.
| Study | Allocation generation; concealment | Binding | Follow-up lost (n) | ITT | Selective Reporting | Unequal baseline or other remarks | ||
|---|---|---|---|---|---|---|---|---|
| Participants | Investigators | Examiners | ||||||
| van Geest2008 | A, A | Y | N | Y | 1 at week 0 | Y | NA | |
| Lee2012 | A, B | N | N | Y | 10 | N | N | Swelling grade |
| Salvi2015 | A, B | Y | N | Y | 1 | N | Y | Protocol amendment |
| Savino2014 | B, B | N | N | N | 1 | N | NA | |
| Prummel1993 | A, B | Y | N | Y | 3 | N | NA | |
| Prummel1989 | A, B | N | N | Y | 0 | Y | NA | |
| Stamato2006 | A, B | Y | N | Y | 3 | N | NA | |
| Kahaly1996 | A, B | N | N | Y | 0 | Y | NA | Visual acuity |
| Ye2016 | A, B | N | N | Y | 16 | N | NA | |
| Kung1996 | A, B | N | N | Y | 0 | Y | NA | CAS |
| Kahaly1986 | C, C | N | N | Y | 0 | Y | NA | |
| Kahaly2018 | A, A | N | Y | Y | 23 | N | N | |
| Chen 2016 | A, B | N | N | N | 0 | Y | NA | |
| Kahaly1990 | B, B | Y | N | Y | 0 | Y | NA | |
| Ng2005 | B, B | N | N | Y | 1 | N | NA | Age |
| Pinchera1987 | A, B | N | N | N | 0 | Y | NA | |
| Rajendram2018 | A, B | Y | Y | Y | 69 | Y | N | Ethnicity |
| Roy2015 | A, B | N | N | N | 3 | N | N | Diplopia, TSH |
| Macchia2001 | B, B | N | N | N | 0 | Y | NA | CAS, OI |
| Akarsu2011 | B, B | N | N | N | 0 | Y | NA | |
| Aktaran2007 | A, A | N | N | Y | 0 | Y | NA | Lid width |
| Kahaly2005 | A, B | N | N | Y | 0 | Y | NA | Lid width |
| Kauppinen-Makelin2002 | A, A | N | N | N | 0 | Y | NA | TSab titers, visual acuity |
| Marcocci2001 | A, B | N | N | Y | 0 | Y | NA | |
| Alkawas2010 | B, B | N | N | N | 5 | N | NA | |
| Bartalena2012 | A, A | Y | N | Y | 6 | Y | NA | Age, gender |
| He2016 | A, B | N | N | Y | 8 | N | NA | |
| Zhu2014 | A, A | N | N | N | 2 | Y | NA | Duration of eye symptoms; TRAb |
| Philip 2013 | B, B | N | N | N | 0 | Y | NA | |
ITT: intention to treat analysis; A: adequate; B: unknown; C: inadequate; N: no; Y: yes; NA: unable to assess; CAS: clinical activity score; TSH: thyroid stimulating hormone; OI: ophthalmopathy index score; TSab: thyroid stimulating antibodies; TRAb: TSH receptor antibody.