Neutrophils are more activated in the peripheral blood and intestinal mucosa of active IBD patients. (a, b) Peripheral blood samples were collected from healthy donors (HC, n = 24), patients with active CD (A-CD, n = 26), patients with CD in remission (R-CD, n = 22), patients with active UC (A-UC, n = 28), and patients with UC in remission (R-UC, n = 16). The whole blood excluding RBC was analyzed by flow cytometry. ∗∗∗
P < 0.001 compared with HC. (c) Immunohistochemical staining of MPO in inflamed intestinal mucosa from healthy control (HC, n = 10), patients with A-CD (n = 10), and patients with A-UC (n = 10). The arrows indicate MPO+ cells. Original magnification × 200. ∗
P < 0.05 compared with HC.