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IFX suppresses the expression of neutrophil-derived S100A8, S100A9, and MPO in intestinal mucosa. Fresh colon biopsies were collected from inflamed mucosa of patients with active CD (n = 12) and active UC (n = 12), and cultured ex vivo with IFX or control human IgG (HIg) (both at 50 μg/ml) for 24 h. Tissues were harvested for detection of expression of S100A8 (a), S100A9 (b), and MPO (c) by qRT-PCR and compared with healthy controls (n = 5). ∗ P < 0.05 and ∗∗ P < 0.01.
