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. 2018 Nov 22;2018:6857042. doi: 10.1155/2018/6857042

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Copyright © 2018 Yebin Lu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

miR-29c was downregulation in PC tissues and bound to TUG1. (a) The expression of miR-29c in human pancreatic cancer tissues was significantly lower than that in peritumoural normal tissues by the qRT-PCR method. (b) Correlation between TUG1 and miR-29c in pancreatic cancer tissues. (c) qRT-PCR was performed to determine the expression of miR-29c in BxPC-3 and PANC-1 cells after Lv-TUG1 shRNA transfection. (d) The predicted binding sequences of miR-29c in TUG1. Mutation was generated in the seed region (red bases) of TUG1. (e, f) The relative luciferase activity was inhibited in BxPC-3 (e) and PANC-1 (f) cells cotransfected with wild-type (wt) TUG1 3′UTR and miR-29c; however, the relative luciferase activity was not inhibited in cells transfected with mutant-type (mut) TUG1 3′UTR. Firefly luciferase activity was normalised to Renilla luciferase. ^∗∗ P < 0.01 vs. NC group.