Table 2.
Gene expression changed in senescence of MRC-5 fibroblasts treated with SFN in vitro (transcriptomics analysis).
| No. | Gene ID | Name | P value | ΔLog2 expression |
|---|---|---|---|---|
| 1 | TXNIP | Thioredoxin-interacting protein | 0.039 | 6.8 |
| 2 | ACKR4 | Atypical chemokine receptor 4 | 0.024 | 5.6 |
| 3 | C11orf87 | Neuronal integral membrane protein 1 | 0.039 | 3.8 |
| 4 | PRRX2 | Paired related homeobox 2 | 0.046 | 3.3 |
| 5 | FZD4 | Frizzled class receptor 4 | 0.005 | 2.5 |
| 6 | ACAA2 | Mitochondrial 3-oxoacyl-coenzyme A thiolase | 0.024 | 2.5 |
| 7 | MOB4 | Mps one binder kinase activator-like 3 | 0.007 | 1.8 |
| 8 | SLC46A1 | Proton-coupled folate transporter | 0.035 | 1.7 |
| 9 | CSNK1G1 | Casein kinase 1 gamma 1 | 0.023 | 1.5 |
| 10 | ACTR2 | Actin-related protein 2 homolog | 0.014 | 1.1 |
| 11 | MAEA | Macrophage erythroblast attacher | 0.016 | 1.1 |
| 12 | GALC | Galactosylceramidase | 0.024 | 1.1 |
| 13 | VAT1 | Vesicle amine transport 1 | 0.019 | 1.1 |
| 14 | ARSJ | Arylsulfatase family member J | 0.004 | 0.9 |
| 15 | SUN1 | Sad1 and UNC84 domain containing 1 | 0.045 | −0.7 |
Genes listed had expression changes between passages 3 and 11 in MRC-5 fibroblasts treated with SFN. Gene expression changes are rank-ordered by log2 expression change (highest to lowest). P values are with Bonferroni-correction applied.