Figure 3.

Mobilized mesenchymal stem cells (MSCs) are indistinguishable from resident synovial fluid (SF)–MSCs. (A) Resident and mobilized MSCs have a comparable immunophenotype, which is consistent with both SF- and synovium-derived MSCs (n = 3 matched donors). (B-D) Resident and mobilized MSCs have comparable trilineage differentiation capacity as demonstrated by quantitative assays (left, n = 5 matched donors) illustrating their chondrogenic, osteogenic, and adipogenic potential, respectively, and qualitative assays (right, representative matched donors).