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. 2018 Dec 4;9(6):e02377-18. doi: 10.1128/mBio.02377-18

TABLE 2.

Grx4-regulated genes encoding iron transport and homeostasis and mitochondrial functions

Result for iron level comparisona :
Gene ID Gene
name		 Function WT low
vs high		 grx4 low
vs WT low		 grx4 high
vs WT high		 grx4 low
vs high
Iron transport
    CNAG_00815 SIT1 Siderochrome-iron uptake transporter 1.86 1.06 2.09 0.94
    CNAG_06761 SIT3 Siderophore-iron transporter Str1 2.29 0.37 0.89 0.96
    CNAG_07387 SIT4 Siderophore-iron transporter 2.81 3.92 10.55 1.04
    CNAG_07519 SIT5 Siderophore-iron transporter 2.23 0.64 2.07 0.68
    CNAG_07751 SIT6 Siderophore iron transporter MirB 3.63 2.32 8.35 1.00
    CNAG_03498 FRE201 Metalloreductase 1.45 2.06 3.39 0.88
    CNAG_06524 FRE3 Ferric reductase 2.50 5.07 16.25 0.77
    CNAG_06976 FRE6 Ferric reductase 2.40 0.66 1.16 1.35
    CNAG_00876 FRE7 Ferric reductase 0.40 0.89 0.49 0.72
    CNAG_03498 FRE8 Ferric reductase 1.45 2.06 3.39 0.88
    CNAG_04864 CIR1 Iron regulator 1 0.81 0.02 0.01 1.23
    CNAG_01242 HAPX Conserved hypothetical protein 1.93 1.21 2.14 1.08
    CNAG_02950 GRX4 Grx4 family monothiol glutaredoxin 1.72 0.11 0.15 1.21
    CNAG_00727 MMT2 Mitochondrial protein with role in iron
accumulation		 0.50 0.89 0.43 1.04
    CNAG_03465 LAC1 Laccase 1 0.99 10.22 7.55 1.32
    CNAG_05154 CCC1 Membrane fraction protein 0.57 5.20 5.50 0.54
    CNAG_07519 SIT1/ARN1 Conserved hypothetical protein 2.23 0.64 2.07 0.68
    CNAG_01653 CIG1 Cytokine inducing-glycoprotein, putative
a hemophore		 2.29 0.64 1.32 1.10
    CNAG_07865 Ferro-O2-oxidoreductase 2.55 0.94 1.99 1.20
Heme biosynthesis
    CNAG_01721 HEM3 Porphobilinogen deaminase 0.15 2.62 1.71 0.22
    CNAG_02460 HEM13 Coproporphyrinogen III oxidase 0.39 0.82 0.27 1.16
    CNAG_03939 HEM1 5-Aminolevulinic acid synthase 0.19 2.52 1.10 0.42
    CNAG_03187 HEM14 Protoporphyrinogen oxidase 0.92 0.45 0.45 0.91
    CNAG_01908 HEM4 Uroporphyrinogen-III synthase 0.04 10.60 2.72 0.14
Mitochondrial ISC
assembly
    CNAG_03395 NFU1 NifU-like protein C 0.10 3.78 1.59 0.25
    CNAG_03589 YAH1 Adrenodoxin-type ferredoxin 0.54 2.24 2.22 0.54
    CNAG_02522 MRS3/4 Carrier 1.25 0.85 1.11 0.95
    CNAG_03985 GRX5 Monothiol glutaredoxin-5 0.45 1.95 2.04 0.43
    CNAG_05199 SSQ1 Heat shock protein 0.41 0.81 0.52 0.64
    CNAG_04288 JAC1 Conserved hypothetical protein 1.78 0.34 0.60 1.01
    CNAG_02131 ISA1 Iron sulfur assembly protein 1 0.32 2.20 1.58 0.44
    CNAG_00491 ISA2 Iron sulfur assembly protein 2 0.92 0.70 0.82 0.77
    CNAG_00389 IBA57 Mitochondrial protein 0.25 2.42 1.17 0.52
Cytosolic ISC
assembly
    CNAG_04202 NAR1 Iron hydrogenase 0.15 3.04 1.61 0.28
    CNAG_01802 DRE2 Cytoplasmic protein 0.50 3.10 2.41 0.63
    CNAG_01137 ACO1 Aconitase 0.21 1.47 1.35 0.23
ISC-containing proteins
    CNAG_07908 ACO2 Aconitate hydratase 0.20 5.64 2.13 0.53
    CNAG_06621 BIO2 Biotin synthase 0.35 1.28 0.98 0.45
    CNAG_00462 CIR2 Oxidoreductase 0.05 8.51 1.35 0.29
    CNAG_01914 COQ11 Mitochondrial protein 0.98 0.58 0.56 1.00
    CNAG_07572 ELP3 Pol II transcription elongation factor 0.27 2.90 1.76 0.44
    CNAG_04862 GLT1 Glutamate synthase 0.22 7.36 7.15 0.22
    CNAG_07491 GRX6 Conserved hypothetical protein 1.06 0.71 0.92 0.82
    CNAG_00237 LEU1 3-Isopropylmalate dehydratase 0.22 9.54 3.01 0.70
    CNAG_05194 LIP5 Lipoic acid synthetase 0.47 1.89 2.16 0.41
    CNAG_02565 LYS4 Homoaconitate hydratase 0.07 8.81 1.64 0.40
    CNAG_05070 MET5 Sulfite reductase beta subunit 0.14 3.60 2.13 0.23
    CNAG_03206 NTG2 DNA-(apurinic or apyrimidinic site) lyase 0.23 3.50 1.89 0.42
    CNAG_02315 RIP1 Ubiquinol-cytochrome c reductase iron-sulfur
subunit		 0.22 2.47 1.30 0.42
    CNAG_07667 SAT4 Other/HAL protein kinase 0.89 0.92 0.83 0.98
    CNAG_07356 SHH3 Succinate dehydrogenase 0.16 2.19 1.13 0.32
    CNAG_06558 TAH18 NADPH-ferrihemoprotein reductase 0.81 3.20 1.82 1.41
Electron transport
    CNAG_05318 CYB2 l-Mandelate dehydrogenase 0.41 2.78 1.84 0.61
    CNAG_05169 CYB2 Cytochrome b2 0.21 4.54 1.86 0.50
    CNAG_07480 MCR1 Cytochrome b5 reductase 2.24 0.95 1.67 1.27
    CNAG_00716 CYC7 Electron carrier 0.22 2.14 1.96 0.23
    CNAG_03666 Acyl-CoA dehydrogenase 0.06 2.83 1.16 0.14
    CNAG_03629 YHB1 NADH-ubiquinone oxidoreductase 0.05 4.30 1.15 0.20
    CNAG_01229 CYB2 l-Mandelate dehydrogenase 0.13 3.91 2.05 0.25
    CNAG_05631 NADH-ubiquinone oxidoreductase 0.07 5.40 1.29 0.30
    CNAG_01078 ALD5 Aldehyde dehydrogenase 1.51 2.39 3.00 1.20
    CNAG_04189 SDH1 Succinate dehydrogenase flavoprotein subunit 0.17 1.52 1.03 0.24
    CNAG_04521 Oxidoreductase 1.40 1.83 2.54 1.00
    CNAG_03663 CYB2 l-Lactate dehydrogenase 0.10 3.02 1.31 0.24
    CNAG_03226 SDH2 Succinate dehydrogenase iron-sulfur subunit 0.09 1.48 0.87 0.15
    CNAG_05179 QCR2 Ubiquinol-cytochrome c reductase complex core 0.17 2.12 0.95 0.37
    CNAG_05258 Glucose-methanol-choline oxidoreductase 5.68 4.72 17.36 1.53
    CNAG_01323 QCR7 Ubiquinol-cytochrome c reductase 0.27 3.20 1.96 0.43
    CNAG_05909 CYT1 Electron transporter 0.12 3.18 1.18 0.32
Mitochondrial functions
    CNAG_00162 Alternative oxidase 0.02 52.56 1.80 0.68
    CNAG_03824 MIR1 Phosphate transport protein MIR1 1.19 0.26 0.31 1.00
    CNAG_00499 Carnitine/acyl carnitine carrier 0.36 1.70 1.04 0.59
    CNAG_05909 Electron transporter 0.12 3.18 1.18 0.32
    CNAG_02315 Ubiquinol-cytochrome c reductase 0.22 2.47 1.30 0.42
    CNAG_05132 Cytochrome c oxidase 0.48 1.14 0.95 0.56
    CNAG_03225 Malate dehydrogenase 0.91 0.56 0.44 1.14
    CNAG_00237 3-Isopropylmalate dehydratase 0.22 9.54 3.01 0.70
    CNAG_03596 Dihydrolipoamide succinyltransferase 0.46 0.87 0.74 0.54
    CNAG_07908 Aconitate hydratase 0.20 5.64 2.13 0.53
    CNAG_05031 Succinyl-CoA:3-ketoacid-coenzyme A transferase 0.96 0.22 0.65 0.32
    CNAG_06138 NADH dehydrogenase (ubiquinone) Fe-S 6 0.22 2.05 1.01 0.45
DNA repair
    CNAG_07552 RAD8 DNA repair Rad8 0.87 6.75 4.97 1.17
    CNAG_00178 REV1 DNA repair REV1 1.40 6.12 7.12 1.19
    CNAG_05198 RAD7 DNA repair RAD7 1.27 5.49 7.27 0.95
    CNAG_02544 SWI5 DNA repair Swi5/Sae3 1.56 5.06 7.04 1.10
    CNAG_02512 RAD16 DNA repair RAD16 1.97 4.84 8.86 1.06
    CNAG_01163 RAD54 DNA repair and recombination RAD54 1.24 3.42 3.98 1.06
    CNAG_00299 RAD5 DNA repair RAD5 0.75 2.82 2.19 0.96
    CNAG_02771 RAD54b DNA repair and recombination RAD54B 1.10 7.91 8.79 0.98
    CNAG_00720 RAD51 DNA repair RAD51 1.51 7.11 10.72 0.99
    CNAG_03637 Double-strand break repair factor and silencing regulator 1.09 3.61 3.71 1.05
Ergosterol metabolism
    CNAG_00519 ERG3 2.18 0.24 0.39 1.30
    CNAG_01129 ERG7 1.66 0.43 0.54 1.32
    CNAG_00854 ERG2 2.46 0.25 0.57 1.08
    CNAG_02830 ERG4 1.82 0.46 0.94 0.88
    CNAG_01737 ERG25 2.19 0.17 0.35 1.06
Oxidative stress
    CNAG_00575 CAT3 Catalase 3 (CAT3) 0.48 5.59 3.31 0.81
    CNAG_00654 SRX1 Conserved hypothetical protein (SRX1, sulfiredoxin) 4.34 4.85 14.41 1.45
    CNAG_01138 CCP1 Cytochrome c peroxidase (CCP1) 0.07 181.00 27.35 0.44
    CNAG_03482 TSA1 Thioredoxin-dependent peroxide reductase (TSA1) 1.31 5.10 4.62 1.44
    CNAG_03985 GRX5 Monothiol glutaredoxin-5 (GRX5) 0.45 1.95 2.04 0.43
    CNAG_04388 SOD2 Mitochondrial superoxide dismutase Sod2 0.98 0.58 0.51 1.12
    CNAG_05847 TRR1 Thioredoxin-disulfide reductase (TRR1) 1.24 12.12 10.13 1.47
a

The numbers in boldface are the measurements where the log2 value is ≥2; the numbers in italic are log2 values of <0.5.