Figure 5.

Model of time courses of neurodevelopment between mice and humans in relation to timing of global ischemia. Impairment of memory and synaptic plasticity is transient, but likely represents several years in a child during which intervention can occur. This model shows the corresponding decrease and recovery in BDNF which contributes to the impairment and endogenous recovery of memory and synaptic function.

BDNF: brain-derived neurotrophic factor; CA/CPR: cardiac arrest/cardiopulmonary resuscitation.