Figure 6.

Model of PgP trafficking in response to PIP. At baseline, PgP is partially distributed in the nucleus, the caveolae and the non-caveolar portions of the membrane. Upon a PIP stimulus, phosphorylation of CAV1 (a) results in the trafficking of PgP in vesicles from the nucleus to the plasma membrane (b). (c) At the plasma membrane, PgP becomes activated (depicted by arrow) and increases drug efflux into the capillaries. Movement of PgP from the caveolae into lipid rafts in the plasma membrane may also occur.