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Over 50% of cases of clinically diagnosed Alzheimer disease (AD) feature vascular pathology. AD represents 70% of cases of late-life dementia, diagnosed according to clinical criteria. However, post-mortem neuropathological analysis reveals that only 24% of dementia cases feature exclusively AD pathology (amyloid plaques and neurofibrillary tangles), while over 50% feature vascular pathology, either alone (26%) or mixed with AD pathology (27%).
