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. 2018 Dec 4;91(23):e2170–e2181. doi: 10.1212/WNL.0000000000006614

Figure 1. Pedigrees of the families analyzed in this study.

Figure 1

(A) Simplified pedigrees of the families who underwent exome analysis. Black + = individuals for which DNA is available; blue square = individuals for whom exome data is available. (B) Pedigrees of additional families carrying missense variants in the PCNT gene. Simplified pedigrees of the families carrying PCNT missense variants. Squares = men; circles = women; black + = individuals for whom DNA is available who were Sanger sequenced; red + = mutated allele; red − = wild-type allele; forward black slash = deceased individual; arrowhead = proband of each family. Families 7019 and 8159 carry the same PCNT p.V2811L missense mutation. Families 8080 and 8091 carry the same PCNT p.A2891T missense mutation. AICS = acute ischemic cerebrovascular syndrome; CTA = computed tomography angiography; IA = intracranial aneurysm; MRA = magnetic resonance angiography; N = normal; NA = not available; SAH = subarachnoid hemorrhage.