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. 2018 Dec 6;16:228. doi: 10.1186/s12916-018-1213-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Two-way sensitivity analysis of the vaccine cost per series of HZ/su and vaccine cost per dose of ZVL for vaccination of a 50-year-olds, b 60-year-olds, c 70-year-olds and d 80-year-olds. After performing a probabilistic sensitivity analysis using 10,000 Monte Carlo simulations, the alternative with the highest probability of being cost-effective to a willingness-to-pay threshold of €20,000 per QALY gained is presented over a range of vaccine cost. Dark coloured areas indicate that the probability of being the most cost-effective alternative is higher than 90%. HZ/su, herpes zoster subunit vaccine; QALY, quality-adjusted life year; ZVL, zoster vaccine live