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. 2018 Dec 6;16:228. doi: 10.1186/s12916-018-1213-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Impact of the inclusion of additional efficacy against PHN using trial data and the use of effectiveness data against HZ on the threshold vaccine cost per dose of ZVL. The cost-effectiveness threshold was set at €20,000 per quality-adjusted life year gained. Effectiveness data from three data sources, i.e. the US Kaiser Permanente Southern California database [14], the US Medicare database [16] and the UK Clinical Practice Research Datalink database [50], were explored. For the Medicare and Clinical Practice Research Datalink database, no effectiveness data of 60-year-olds was available. PHN, post-herpetic neuralgia; QALY, quality-adjusted life year; ZVL, zoster vaccine live