Table 2.

Summary of main results.

	Relative effect from meta-analysis	Calculated absolute effect	Minimal clinically important relative effect	Minimal clinically important absolute effect
Annual exacerbation rate	53% reduction (95% CI: 46; 59 %)	−0.94 (95% CI −1.08; −0.82)	25%	0.5 exacerbations
Number of patients who experience 0 exacerbations annually	Risk ratio: 1.42 (95% CI 1.30; 1.56)	16.9%-points (95% CI 12.1; 22.5)	-	10%-points
Average %-reduction in daily dose OCS	NA	NA	0.2	2.5-mg prednisolone equivalent
Percentage of patients who experience ≥50% reduction OCS	1.61 (95% CI 1.07–2.41)	20.3%-point (95% CI 2.3; 47.0)	-	10%-points
Percentage of patients who are discontinued OCS	1.91 (95% CI 0.69; 5.30)	6.9%-point (95% CI −2.3–32.6)	-	5%-points
Average change in FEV1	-	112.9 ml (95% CI: 82.4; 143.4)	-	200 ml
Percentage of patients who experience an improvement of 200 ml or more	NA	NA	-	15%-points
Average change in ACQ	-	−0.29 point (95% CI: – 0.36; – 0.23)	-	ACQ: 0.5
Average change in AQLQ	-	0.32 point (95% CI: 0.22; 0.43)	-	AQLQ: 0.5
Percentage of patients who experience SAE	0.73 (95% CI: 0.57; 0.92)	−2.4%-point (95% CI: −0.7; −3.8)	-	5%-points
Percentage of patients dropout	0.85 (95% CI: 0.69; 1.05)	−2.3%-point (95% CI: −4.7; 0.7).	-	10%-points