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. 2018 Dec 4;56(1):594–611. doi: 10.1080/13880209.2018.1517185

Figure 11.

Figure 11.

INH/RIF-induced liver injury. INH/RIF trigger the continuous development of hepatocyte injury by inducing cell stress via inflammation, cholestasis, and metabolic disorder, resulting in hepatic necrosis, apoptosis, and liver injury. CYP450: cytochrome P450; PPAR: peroxisome proliferator-activated receptors.