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. 2018 Oct 9;104(6):1062–1073. doi: 10.1002/cpt.1208
Prevention, not just control, of infection to limit the establishment of proviral reservoirs
Generation of highly mutated Ab with atypical structures to achieve broad neutralization
Providing CD4+ T cell help that is not kindling for infection
Achieving breadth for the diversity of transmitted viruses

Ab, antibody; HIV, human immunodeficiency virus.