Figure 1.

(a) An illustration of neutrophil maturation stages, time of NSP activation, and expected neutrophil maturation rates in healthy individuals.3, 22 (b) Outline of the final model used to describe AZD7986 PK and NE activity data. AZD7986 PK was modeled by a three‐compartment model (upper part) and whole blood NE activity by a transit compartment model (lower part). AZD7986 plasma concentrations were assumed to inhibit the amount of active NE entering the first transit bone marrow (bm) compartment.