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. 2018 Apr 16;104(6):1155–1164. doi: 10.1002/cpt.1053

Figure 2.

Figure 2

Observed geometric mean AZD7986 plasma concentrations after single/first dose (a) and after once‐daily dosing for 21 or 28 days (b). Data shown in (a) come from both Parts I and II, while data shown in (b) come from Part II only. In Part I, plasma concentrations were measured for up to 96 hours following a single dose of AZD7986. In Part II, plasma concentrations were measured for up to 24 hours following the first dose and 96 hours following the last dose of AZD7986. (c,d) Visual predictive checks (VPCs) of the final PK model. VPCs were prediction‐corrected and stratified on day (c = first dose, d = Day 21/28). Black dots show the individual observations. Blue lines show the 5th and 95th percentiles of the observed data, and red lines show the median of the observed data. The blue and red shaded areas show the 95% CIs of the model‐predicted 5th, median, and 95th percentiles based on simulated data from 1,000 simulations.