Figure 5.

Estimated mean and 95% CIs for the steady‐state dose (a) and exposure (b) response of whole blood NE activity after once‐daily dosing with AZD7986. The mean level of inhibition and confidence intervals were derived using population typical PK and PD parameters and their estimated variance‐covariance. Percentages shown in (a) indicate the estimated mean inhibition for the three once‐daily doses (10, 25, and 40 mg) of AZD7986 studied in Part II. (c,d) Simulations with the final model highlighting the response of the system at different doses (c) and after a period of 0‐14 days of missed doses (d). Red numbers in (d) indicate number of missed doses.