Table 2.
Diagnostic accuracy of APRI, Fib‐4 and GPR using LSM as a reference in patients with chronic hepatitis C
| F0‐1 vs F2‐4 | F0‐3 vs F4 | |||
|---|---|---|---|---|
| APRI | ||||
| AUROC (95% CI) | 0.58 (0.41‐0.75) | 0.51 (0.06‐0.97) | ||
| Cut‐off values | 0.5 | 1.5 | 1.0 | 2.0 |
| Sensitivity/specificity (%) | 73/34 | 27/88 | 50/77 | 25/95 |
| Correctly classified (%) | 41 | 77 | 76 | 92 |
| PPV/NPV (%) | 20/85 | 33/84 | 10/97 | 20/96 |
| Positive/negative LR | 1.1/0.8 | 2.2/0.8 | 2.2/0.7 | 4.9/0.8 |
| Fib‐4 | ||||
| AUROC (95% CI) | 0.51 (0.34‐0.68) | 0.48 (0.09‐0.87) | ||
| Cut‐off values | 1.45 | 3.25 | ||
| Sensitivity/specificity (%) | 43/50 | 14/92 | ||
| Correctly classified (%) | 49 | 78 | ||
| PPV/NPV (%) | 16/80 | 29/83 | ||
| Positive/negative LR | 0.9/1.1 | 1.8/0.9 | ||
| GPR | ||||
| AUROC (95% CI) | 0.56 (0.37‐0.75) | 0.62 (0.34‐0.90) | ||
| Cut‐off values | 0.28 | 0.28 | ||
| Sensitivity/specificity (%) | 69/40 | 75/39 | ||
| Correctly classified (%) | 45 | 41 | ||
| PPV/NPV (%) | 19/87 | 6/97 | ||
| Positive/negative LR | 1.2/0.8 | 1.2/0.6 | ||
AUROC, area under the receiving operator curve; PPV, positive predictive value; NPV, negative predictive value.