Table 3.
Parameter estimates from the Clinical Practice Research Datalink example estimated from the treatment‐naïve model and the marginal structural model (MSM). All of the variables are those extracted at baseline (ie, the index date). Note that both models include a year‐specific intercept fitted as a restricted cubic spline
| Variable | Treatment Naïve Model (SE) | MSM (SE) |
|---|---|---|
| Statin Initiation | N/A | −0.1002 (0.0103) |
| Female | −0.5566 (0.0066) | −0.5331 (0.0062) |
| Age | 0.0711 (0.0003) | 0.0723 (0.0002) |
| Atrial Fibrillation | 0.4827 (0.0156) | 0.4353 (0.0148) |
| Chronic Kidney Disease (stage 4/5) | 0.3646 (0.0352) | 0.3612 (0.0318) |
| Type I diabetes | 0.7307 (0.0585) | 0.5859 (0.0564) |
| Type II diabetes | 0.5967 (0.0138) | 0.5414 (0.0128) |
| Ethnicity | ||
| White or not stated | Reference | Reference |
| Asian | −0.0840 (0.0700) | −0.1936 (0.0679) |
| Bangladesh | 0.1343 (0.1557) | 0.1191 (0.1504) |
| Black | −0.6454 (0.0568) | −0.7092 (0.0536) |
| Chinese | −0.7970 (0.1629) | −0.7965 (0.1553) |
| Indian | −0.0250 (0.0498) | 0.0787 (0.0440) |
| Mixed | −0.6138 (0.1287) | −0.6547 (0.1229) |
| Other | −0.3416 (0.0758) | −0.2489 (0.0674) |
| Pakistani | 0.3351 (0.0794) | 0.3109 (0.0766) |
| Family history of coronary heart disease | 0.1391 (0.0088) | 0.1172 (0.0082) |
| Hypertension | 0.1390 (0.0078) | 0.2553 (0.0072) |
| Rheumatoid arthritis | 0.4200 (0.0237) | 0.4072 (0.0220) |
| Systolic blood pressure | 0.0109 (0.0002) | 0.0104 (0.0002) |
SE = standard error.