Figure 1.

Study design. (A) Core study. (B) Extension phase. AVA, avatrombopag; CONMED, concomitant medication; E, extension; EOT, end‐of‐treatment; ITP, immune thrombocytopenia; PBO, placebo; qd, once‐daily; R, randomised. *At EOT visit (visit 22), patients could enter the extension phase and receive open‐label avatrombopag therapy. Patients who did not continue into the extension phase entered the dose‐tapering and follow‐up phase. ^†Only for patients who did not enter the extension phase. ^‡Optional entry into the open‐label extension phase. ^§The screening visit and day 1 baseline/randomisation visit platelet counts were averaged to obtain the baseline platelet count value. The two samples were obtained ≥48 h and ≤2 weeks apart and the results were available prior to randomisation. Therefore, an additional screening platelet count may have been required due to issues with scheduling. ^‖Patients who discontinued early who met the criteria for a lack of treatment effect may have moved directly into the open‐label extension phase. [Colour figure can be viewed at http://wileyonlinelibrary.com]