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. 2018 Nov 8;13(21):2271–2280. doi: 10.1002/cmdc.201800487

Scheme 5.

Scheme 5

Synthesis of the biphenylcarboxylic acid 11: a) ammonium formate, Pd/C, methanol, RT; b) C4F9SO2F, nBuLi, THF, 0 °C; c) [4‐(methoxycarbonyl)phenyl]boronic acid, Pd(PPh3)4, toluene/ethanol, reflux; d) acetic acid, 35 °C; e) LiOH, THF, 90 °C.