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. 2018 Sep 5;33(10):1591–1600. doi: 10.1002/mds.64

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© 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Power analysis. Power estimation for sequence kernel association test (SKAT) and weighted burden test using the rare variant matrix from the ParkWest dataset as basis for the simulation. Genome‐wide significance levels were set to α = 2.5 × 10⁻⁶, assuming a total of 20,000 genes. The y‐axis shows the average power across all genes, and the x‐axis shows total sample size. Simulations were made for different percentages of causal variants.