Table 2.
Model 1 |
Model 2 |
Model 3 |
Model 4 |
Model 5 |
Model 6 |
Model 7 |
|
---|---|---|---|---|---|---|---|
β (95% CI) per 5 mm Hg of systolic BP | β (95% CI) per 5 mm Hg of systolic BP | β (95% CI) per 5 mm Hg of systolic BP | β (95% CI) per 5 mm Hg of systolic BP | β (95% CI) per 5 mm Hg of systolic BP | β (95% CI) per 5 mm Hg of systolic BP | β (95% CI) per 5 mm Hg of systolic BP | |
A. Pre-exercise systolic BP | |||||||
LV Mass, g (n = 1768) |
4.883 (4.359, 5.407)a | 4.884 (4.359, 5.408)a | 4.857 (4.335, 5.378)a | 1.253 (0.816, 1.690)a | 0.729 (0.324, 1.133)a | 0.617 (0.173, 1.061)a | 0.541 (−0.022, 1.105) |
LVMI, g/m2.7 (n = 1756) |
0.568 (0.464, 0.671)a | 0.568 (0.464, 0.671)a | 0.555 (0.456, 0.655)a | 0.339 (0.226, 0.452)a | 0.216 (0.110, 0.323)a | 0.191 (0.076, 0.307)a | 0.145 (−0.002, 0.293) |
LA size, cm (n = 1603) |
0.038 (0.031, 0.045)a | 0.038 (0.031, 0.045)a | 0.038 (0.031, 0.045)a | 0.012 (0.005, 0.020)a | 0.004 (−0.003, 0.011) | 0.000 (−0.002, 0.013) | 0.010 (0.000, 0.019) |
RWT (n = 1768) |
0.002 (0.001, 0.003)a | 0.002 (0.001, 0.003)a | 0.002 (0.001, 0.003)a | 0.002 (0.001, 0.003)a | 0.002 (0.001, 0.003)a | 0.002 (0.001, 0.003)a | 0.001 (−0.001, 0.002) |
Aortic PWV, m/s (n = 2965) |
0.068 (0.060, 0.077)a | 0.068 (0.059, 0.077)a | 0.069 (0.060, 0.078)a | 0.041 (0.032, 0.050)a | 0.043 (0.033, 0.052)a | 0.037 (0.030, 0.045)a | 0.015 (0.002, 0.027)a |
cIMT, mm (n = 3687) |
0.002 (0.001, 0.002)a | 0.002 (0.001, 0.002)a | 0.002 (0.001, 0.002)a | 0.001 (0.000, 0.001)a | 0.001 (0.000, 0.001)a | 0.001 (0.000, 0.002)a | 0.000 (0.000, 0.001) |
B. Post-exercise systolic BP | |||||||
LV Mass, g (n = 1747) |
2.357 (1.908, 2.806)a | 2.357 (1.908, 2.807)a | 2.239 (1.784, 2.695)a | 1.094 (0.771, 1.417)a | 0.481 (0.174, 0.789)a | 0.411 (0.096, 0.725)a | 0.301 (−0.067, 0.668) |
LVMI, g/m2.7 (n = 1734) |
0.383 (0.298, 0.468)a | 0.383 (0.299, 0.468)a | 0.302 (0.219, 0.385)a | 0.295 (0.212, 1.379)a | 0.152 (0.071, 0.232)a | 0.131 (0.049, 0.213)a | 0.092 (−0.003, 0.188) |
LA size, cm (n = 1580) |
0.023 (0.017, 0.029)a | 0.023 (0.017, 0.029)a | 0.018 (0.012, 0.024)a | 0.014 (0.008, 0.019)a | 0.004 (−0.002, 0.009) | 0.004 (−0.001, 0.009) | 0.005 (−0.001, 0.011) |
RWT (n = 1747) |
0.002 (0.001, 0.002)a | 0.002 (0.001, 0.002)a | 0.002 (0.001, 0.002)a | 0.002 (0.001, 0.002)a | 0.001 (0.001, 0.002)a | 0.001 (0.000, 0.002) | 0.001 (0.000, 0.002) |
Aortic PWV, m/s (n = 2902) |
0.038 (0.030, 0.045)a | 0.037 (0.030, 0.045)a | 0.044 (0.036, 0.051)a | 0.026 (0.019, 0.033)a | 0.029 (0.022, 0.037)a | 0.029 (0.021, 0.037)a | 0.010 (0.001, 0.019)a |
cIMT, mm (n = 3607) |
0.001 (0.000, 0.001)a | 0.001 (0.000, 0.001) | 0.001 (0.001, 0.001)a | 0.000 (0.000, 0.001) | 0.000 (0.000, 0.001) | 0.001 (0.000, 0.001) | 0.000 (0.000, 0.001) |
C. Recovery-exercise systolic BP | |||||||
LV Mass, g (n = 1708) |
3.984 (3.439, 4.530)a | 3.986 (3.440, 4.531)a | 3.872 (3.325, 4.420)a | 1.246 (0.826, 1.666)a | 0.513 (0.119, 0.908)a | 0.417 (0.010, 0.825)a | 0.226 (−0.266, 0.718) |
LVMI, g/m2.7 (n = 1695) |
0.534 (0.430, 0.639)a | 0.381 (0.295, 0.466)a | 0.466 (0.365, 0.568)a | 0.356 (0.248, 0.464)a | 0.185 (0.082, 0.287)a | 0.159 (0.053, 0.265)a | 0.111 (−0.017, 0.239) |
LA size, cm (n = 1543) |
0.032 (0.025, 0.040)a | 0.032 (0.025, 0.039)a | 0.027 (0.020, 0.035)a | 0.013 (0.006, 0.020)a | 0.001 (−0.006, 0.008) | 0.001 (−0.006, 0.008) | 0.001 (−0.008, 0.010) |
RWT (n = 1708) |
0.002 (0.002, 0.003)a | 0.003 (0.002, 0.004)a | 0.003 (0.002, 0.003)a | 0.002 (0.001, 0.003)a | 0.002 (0.001, 0.003)a | 0.002 (0.001, 0.003)a | 0.001 (0.000, 0.003) |
Aortic PWV, m/s (n = 2846) |
0.068 (0.058, 0.077)a | 0.068 (0.058, 0.077)a | 0.071 (0.062, 0.081)a | 0.043 (0.033, 0.052)a | 0.045 (0.036, 0.055)a | 0.047 (0.037, 0.057)a | 0.024 (0.011, 0.036)a |
cIMT, mm (n = 3531) |
0.002 (0.001, 0.002)a | 0.002 (0.001, 0.002)a | 0.002 (0.001, 0.002)a | 0.001 (0.000, 0.001) | 0.001 (0.000, 0.001) | 0.001 (0.000, 0.001) | 0.000 (0.000, 0.001) |
Results presented as unit change (β) in outcome per 5 mm Hg increase in systolic BP. LV, left-ventricular; LA, left-atrial; RWT, relative wall thickness; cIMT, carotid intima media thickness; PWV, pulse wave velocity. Model 1 - univariable; Model 2 - adjusted for age (years); Model 3 - model 2 plus adjustment for total body fat mass (kg); Model 4 - model 2 plus adjustment for lean mass (kg); Model 5 - model 2 plus adjustment for total body fat mass (kg) and total lean mass (kg); Model 6 - model 5 plus adjustment for hypertension status (resting SBP and/or DBP ≥ 140/90 mm Hg - yes/no); Model 7 - model 5 plus adjustment for office resting SBP.
Indicates confidence intervals do not cross zero.