Table 2.
Descriptive data of controlled ovarian stimulation, oocytes, embryo transfer, and luteal phase support.
| 17-OH P4, nmol/l | All | <6 | 6-14 | 14.1-30 | >30 | p |
|---|---|---|---|---|---|---|
| Number of patients (n) | 614 | 183 | 134 | 132 | 165 | |
| Protocol Antagonist (%) Long GnRH agonist (%) | 63 37 | 51 49 | 58 42 | 61 39 | 81 19 | <0.001 |
| Total FSH dose (IU) | 2,250 (500–7,350) | 2,450 (900–6,750) | 2,063 (788–7350) | 2,475 (900–5025) | 1,950 (500–7,350) | <0.001 |
| Stim duration (days) | 10.4 ± 2.0 | 10.4 ± 1.9 | 10.6 ± 2.1 | 10.6 ± 2.1 | 9.9 ± 1.9 | 0.006 |
| Final follicle count >12 mm on trigger day | 10 (1–29) | 10 (1–29) | 9 (1–22) | 9 (3–20) | 10 (1–26) | 0.005 |
| Mode of triggering for final oocyte maturation | ||||||
| hCG (%) | 58 | 67 | 72 | 61 | 35 | <0.001 |
| GnRH agonist (%) | 42 | 33 | 28 | 39 | 65 | |
| Number of oocytes retrieved (n) | 8 (1–28) | 9 (1–23) | 8 (1–26) | 8 (1–24) | 9 (2–28) | 0.014 |
| Number of fertilized oocytes (n) | 8 (1–27) | 8 (1–23) | 8 (1–23) | 7 (1–24) | 8 (2–27) | 0.033 |
| Single embryo transfer (%) Double embryo transfer (%) | 81 19 | 79 21 | 79 21 | 83 17 | 83 17 | 0.661 |
| At least one top quality embryo for transfer (%) | 64 | 66 | 59 | 70 | 64 | 0.160 |
| Mean embryo score, SET DET | 1.4 ± 0.6 1.7 ± 0.6 | 1.4 ± 0.6 1.7 ± 0.6 | 1.5 ± 0.7 1.7 ± 0.7 | 1.3 ± 0.5 1.6 ± 0.7 | 1.5 ± 0.7 1.6 ± 0.6 | 0.090 0.915 |
| Day of transfer, Cleavage-stage embryo transfer (%) Blastocyst transfer (%) | 72 28 | 72 28 | 72 28 | 77 23 | 68 32 | 0.418 |
| Luteal phase support Vaginal progesterone only (%) + 1 bolus of hCG (%) + 2 boluses of hCG (%) Vaginal P + Gonapeptyl (%) | 52 17 25 6 | 61 28 4 7 | 66 19 8 7 | 53 9 30 8 | 31 9 56 4 | <0.001* <0.001 <0.001 0.353 |
Descriptive data is presented as mean ± SD for continuous parametric data and as median (range) for continuous non-parametric data. Categorical data is presented as percentages (%).
*
p-value describes the comparison between the chosen luteal phase support category and the combined group of all other luteal phase support categories. SI conversion factor for 17-OH P4: nmol/l = 3.03 * ng/ml.