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. 2018 Sep 10;42(11):2107–2122. doi: 10.1111/acer.13871

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© 2018 The Authors Alcoholism: Clinical & Experimental Research published by Wiley Periodicals, Inc. on behalf of Research Society on Alcoholism

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Hepatic TLR7 mRNA expression is increased in patients with AH and correlates with liver injury and IL‐8 mRNA levels in humans. (A) RNAseq was performed on liver tissue from alcoholic hepatitis (AH; n = 29), nonalcoholic steatohepatitis (NASH; n = 9), or normal fragments of tissue (control, n = 10). TLR7 mRNA levels are shown as transcripts per kilobase million (TPM). (B) TLR7 mRNA expression was validated in a separate cohort of control (n = 7) and AH (n = 17) liver tissues by qPCR. Correlations between hepatic TLR7 and (C) serum AST or (D) hepatic IL‐8 were determined by Pearson's coefficient. mRNA expression data are shown as mean ± SEM. a, p < 0.05 compared to control.