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. Author manuscript; available in PMC: 2018 Dec 6.
Published in final edited form as: Horm Behav. 2015 Apr 17;71:60–68. doi: 10.1016/j.yhbeh.2015.04.004

Fig. 6.

Fig. 6.

PrlR recruits fast STAT5-independent signaling pathways to acutely modify the biophysical properties of cells in the preoptic region. A–C. Current-clamp recordings of MPA neurons unresponsive to prolactin (A), responsive of a female on diestrus (B) and responsive of a lactating N-STAT5 KO female (C). Dashed lines indicate the resting membrane potential. D. Identification of prolactin excited neuron in the MPA for whole-cell patch-clamp recording (low magnification for anatomical reference). E. Bar graphs showing the change in the membrane potential of unresponsive (n = 14) and responsive (female on diestrus, n = 4; lactating female, n = 2) MPA neurons after prolactin application. F. I–V plot from MPA neurons responsive to prolactin (n = 14) illustrating the characteristic reduction in input resistance during the prolactin-induced depolarization (reversal = −31 mV). Abbreviations: 3v, third ventricle. *p < 0.01 compared to unresponsive cells (one-way ANOVA followed by Newman–Keuls test).