Table 3.
Exposure | Age group | Reference (for categorical exposures) | Unadjusted hazard ratio (95% CI) | Unadjusted P value | Fully adjusted hazard ratio (95% CI) | Fully adjusted P value |
---|---|---|---|---|---|---|
Age 45‐54.9 y | ‐ | Under 45 | 1.37 (1.29, 1.45) | <.0001 | 1.79 (1.71, 1.81) | <.0001 |
Age ≥55 y | 2.13 (2.01, 2.24) | <.0001 | 1.48 (1.42, 1.55) | <.0001 | ||
Baseline age (1 y increment within age group) | Under 45 | ‐ | 1.08 (1.07, 1.10) | <.0001 | 1.04 (1.03, 1.06) | <.0001 |
45‐54.9 | 1.10 (1.09, 1.11) | <.0001 | 1.07 (1.06, 1.08) | <.0001 | ||
55 or older | 1.09 (1.08, 1.10) | <.0001 | 1.08 (1.07, 1.09) | <.0001 | ||
Combined | 1.09 (1.08, 1.10) | <.0001 | 1.07 (1.07, 1.08) | <.0001 | ||
Current smoker | Under 45 | Nonsmoker | 2.53 (2.22, 2.88) | <.0001 | 1.80 (1.57, 2.07) | <.0001 |
45‐54.9 | 2.08 (1.89, 2.28) | <.0001 | 1.57 (1.43, 1.74) | <.0001 | ||
55 or older | 1.74 (1.60, 1.89) | <.0001 | 1.56 (1.43, 1.70) | <.0001 | ||
Combined | 1.87 (1.98, 2.10) | <.0001 | 1.62 (1.53, 1.71) | <.0001 | ||
Groundschool or equivalent | Under 45 | Elementary school | 0.65 (0.51, 0.84) | .001 | 0.79 (0.62, 1.02) | .067 |
45‐54.9 | 0.85 (0.75, 0.95) | .006 | 0.82 (0.73, 0.92) | .001 | ||
55 or older | 0.87 (0.80, 0.93) | <.0001 | 1.01 (0.94, 1.09) | .754 | ||
Combined | 0.84 (0.79, 0.90) | <.0001 | 0.92 (0.87, 0.98) | .011 | ||
Highschool or equivalent | Under 45 | Elementary school | 0.55 (0.47, 0.64) | <.0001 | 0.76 (0.65, 0.90) | .001 |
45‐54.9 | 0.65 (0.59, 0.72) | <.0001 | 0.91 (0.82, 1.01) | .072 | ||
55 or older | 0.83 (0.76, 0.91) | <.0001 | 1.10 (1.01, 1.21) | .033 | ||
Combined | 0.83 (0.73, 0.91) | <.0001 | 0.98 (0.92, 1.04) | .467 | ||
University/College or equivalent | Under 45 | Elementary school | 0.46 (0.39, 0.55) | <.0001 | 0.70 (0.58, 0.84) | <.0001 |
45‐54.9 | 0.75 (0.69, 0.82) | <.0001 | 0.85 (0.76, 0.96) | .01 | ||
55 or older | 0.61 (0.54, 0.68) | <.0001 | 0.99 (0.90, 1.09) | .856 | ||
Combined | 0.66 (0.62, 0.70) | <.0001 | 0.91 (0.85, 0.97) | .006 | ||
Female sex | Under 45 | Male sex | 1.09 (1.00, 1.20) | .055 | 1.11 (1.01, 1.22) | .032 |
45‐54.9 | 1.16 (1.08, 1.25) | <.0001 | 1.11 (1.03, 1.19) | .005 | ||
55 or older | 1.00 (0.94, 1.06) | .962 | 0.97 (0.91, 1.03) | .355 | ||
Combined | 1.07 (1.03, 1.12) | .001 | 1.04 (1.00, 1.08) | .071 |
The fully adjusted estimates are obtained from a multivariable model which also includes adjustment for parameters given in Table 2.