Table 1.

Samples used in this study

Location	Institution	Samples	Gene region
Paris	Institut Curie, Saint Cloud	686 cases	BRCA1 5′region, BRCA2 5′region
Milan	IFOM, Fondazione Instituto FIRC di Oncologia Molecolare	772 cases 661 controls	BRCA1 5′region
Pisa	Department of Translational Research and New Technologies in Medicine, University of Pisa	80 cases	BRCA1 5′region, BRCA2 5′region
Santiago de Compostela	Fundación Pública Galega de Medicina Xenómica‐SERGAS, Grupo de Medicina Xenómica‐USC, CIBERER, IDIS	270 cases 130 controls	BRCA1 5′region, BRCA2 5′region
Copenhagen	Center for Genomic Medicine	1157 cases	BRCA1 5′region, BRCA2 5′region
Ghent	Center for Medical Genetics, Ghent University Hospital	357 cases	BRCA1 5′region, BRCA2 5′region
Barcelona	Vall d'Hebron Institute of Oncology	192 cases	BRCA1 5′region, BRCA2 5′region
Prague	CZECANCA – CZEch CAncer panel for Clinical Aplication, Institute of Biochemistry and Experimental Oncology	2961 cases 312 controls	BRCA1 5′region, BRCA2 5′region
Maastricht	Department of Clinical Genetics, Maastricht University Medical Centre	900 cases	BRCA2 5′region