Table 3.

Complications and Adverse Events

Outcome	Alteplase, n = 23	Fingolimod + Alteplase, n = 23	p
Complications, n (%)
Deaths	4 (17)	0 (0)	0.109
Myocardial infarctions	0 (0)	0 (0)	1.000
Recurrent strokes	0 (0)	1 (4)	1.000
Cerebral herniation	6 (26)	2 (9)	0.243
Hemorrhage of digestive tract	0 (0)	0 (0)	1.000
Fever, > 38°	1 (8)	0 (0)	1.000
Adverse events, n (%)
Any adverse event leading to discontinuation	0 (0)	0 (0)	1.000
Any serious adverse event	0 (0)	0 (0)	1.000
Other adverse events of interest, n (%)
Suspected lung infection	4 (17)	3 (13)	1.000
Urinary tract infection	0 (0)	0 (0)	1.000
Herpes virus infection	0 (0)	0 (0)	1.000
Abnormal laboratory liver function test	0 (0)	0 (0)	1.000
Gastrointestinal disorders	0 (0)	0 (0)	1.000
Thrombocytopenia	0 (0)	2 (9)	0.489
Bradycardia	0 (0)	0 (0)	1.000
Atrial flutter	0 (0)	2 (9)	0.489
Macular edema	0 (0)	0 (0)	1.000