Table 2.
Immune activation and LPS levels according to NSBB treatment and presence of circulating bactDNA fragments
| No NSBB treatment | NSBB treatment | P value (NSBB vs No NSBB) | |||
|---|---|---|---|---|---|
| Absence of bactDNA | Presence of bactDNA | Absence of bactDNA | Presence of bactDNA | ||
| N | 22 | 11 | 20 | 10 | |
| LPS (UI/L) | 0.29 [0.15‐0.34] | 0.72 [0.56‐0.90]a | 0.47 [0.34‐0.52]b | 0.39 [0.37‐0.62] | .17 |
| Serum markers of Inflammatory activation | |||||
| IFN‐gamma (pg/mL) | 6.0 [1.1‐9.0] | 11.0 [9.1‐14.0]a | 9.1 [6.7‐10.0] | 9.4 [7.0‐11.0] | .62 |
| IL10 (pg/mL) | 7.2 [1.3‐10.0] | 18.0 [12.0‐23.0]a | 11.0 [3.2‐16.0] | 14.0 [11.0‐16.0] | .17 |
| IL6 (pg/mL) | 18.0 [13.0‐21.0] | 34.0 [27.0‐38.0]a | 32.0 [23.0‐47.0]b | 30.0 [24.0‐32.0] | .002 |
| TNF‐alpha (pg/mL) | 22.0 [19.0‐24.0] | 21.0 [18.0‐29.0] | 19.0 [16.0‐22.0] | 20.0 [17.0‐26.0] | .15 |
| NO (pg/mL) | 85.0 [62.0‐97.0] | 81.0 [59.0‐116.0] | 80.0 [45.0‐94.0] | 101.0 [70.0‐120.0] | .51 |
bactDNA, bacterial DNA; INF, interferon; LPS, gram‐negative bacterial endotoxin; NO, nitric oxide; NSBB, non‐selective beta‐blocker; TNF, tumour necrosis factor.
Data are expressed as median [Q25‐Q75].
a
P < .05 vs absence of bactDNA.
b
P < .05 vs equivalent bactDNA group in patients non‐treated with BB.