Table 1.
Characteristics of Discovery and Validation Datasets with the Mean (SD) Listed for the Continuous Variables and Count (%) for the Categorical Variables
| Characteristic | Discovery, n = 390 | Validation, n = 1,035 | Difference (95% CI) | p |
|---|---|---|---|---|
| Age, yrs | 75.5 (8.5) | 75.6 (8.6) | −0.12 (−1.12, 0.88) | 0.81 |
| Males, n (%) | 215 (55%) | 552 (53%) | 1.8% (−4.0%, 7.6%) | 0.54 |
| APOE4 carrier, n (%) | 110 (28%) | 296 (29%) | −0.4% (−5.7%, 4.9%) | 0.89 |
| Education, yr | 14.6 (2.6) | 14.7 (2.8) | −0.06 (−0.38, 0.26) | 0.72 |
| Job score | 3.4 (1.4) | 3.3 (1.5) | 0.06 (−0.11, 0.23) | 0.51 |
| Education–occupation composite | 12.5 (2.5) | 12.5 (2.7) | 0.002 (−0.31, 0.31) | 0.99 |
| Cardiometabolic condition, CMC | 2.2 (1.5) | 2.3 (1.6) | −0.11 (−0.29, 0.07) | 0.24 |
| Amyloid deposition, PiB SUVR | 1.41 (0.17) | 1.58 (0.41) | −0.17 (−0.21, −0.13) | <0.001 |
| Global cognition z domain | 0.12 (1.07) | −0.14 (1.18) | 0.27 (0.13, 0.41) | <0.001 |
CI = confidence interval; CMC = cardiovascular and metabolic conditions; PiB = Pittsburgh compound B; SD = standard deviation; SUVR = standardized uptake value ratio.