Table 1.

Comparison of different evaluation strategies. max family‐wise error rate (FWER) is the maximum family‐wise error of the strategy, N is the total sample size, % superior is the percentage of patient studied in the better performing subgroup, and duration is the time from recruiting the first patient until the primary endpoint is available for all patients

Strategy	max FWER	N	% superior	Duration (Months)
Separate studies	0.0494	616	50%	27.64
Single‐stage study	0.0250	684	50%	30.36
Two‐stage design	0.0250	552	75%	25.08 or 36.12